Langerhans Cell Histocytosis

A major field of our research is directed towards understanding the basic biology of histiocytic diseases. We have been studying a human form of histiocytosis called Langerhans cell histiocytosis (LCH) for many years. In this disease, cells called Langerhans cells accumulate in various tissues to form cancer-like lesions. The causes and mechanisms controlling the development of LCH are presently unknown.

LCH is a rare cancer-like disease that mostly affects infants and children but can also occur in adults. Lesions can infiltrate any organ of the body, which can result in bone lesions and scarring of vital organs. Our research has the potential to unlock broad new findings to better understand LCH and other diseases involving the immune system, such as cancer and autoimmunity.

In October 2017, we welcomed long term collaboration project partner, Professor Jan Inge Henter from the Karolinska Institute in Stockholm, Sweden. The visit was a wonderful opportunity to promote the Institute’s groundbreaking research into rare cancer, Langerhans Cell Histiocytosis(LCH). This Visiting Professorship was funded as part of the recently established John Turner Cancer Research Fund and is a beneficial relationship and connection for the Institute.



Group Leaders
  • Professor George Kannourakis
  • Dr. Sharon Olsen
PhD Candidates
  • Jenee Mitchell