Each day 396 Australians will be diagnosed with cancer. Families and friends are shattered by the way a challenging illness affects their loved ones and every day people continue to die. Diagnosis and treatments are improving all the time. But whilst this disease kills, we must continue our part in researching for a cure.
Our research team continues to learn how the immune system can fight cancer, with this approach becoming the future treatment alternative to chemotherapy and radiotherapy. Our key projects are in Immunology, Breast cancer, Bowel cancer, Brain cancer, Ovarian cancer, Chronic lymphocytic leukaemia and Langerhans cell histiocytosis.
I am proud of the progression of our work into the immunology of cancer. Our valuable tissue bank is a powerful and differientating factor to our research. The Institute is in a unique position to study human sequential samples from patients. The group are working to identify new proteins on the cell surface that enable cancer cells to escape immune detection, by creating a camouflaging “fog” around these cells. By studying these patient samples, we will unveil the proteins that drive disease, leading to new treatment development of druggable antibody targets to “lift the fog” from these cells
Recent results include:
• Identification of proteins involved in the mechanism of chemo resistance in Ovarian cancer that can potentially be used as targets to prevent progression and circumvent chemoresistance in Ovarian cancer patients.
• Finding the association of cells and immune checkpoint mechanisms in Gallbladder cancer. This research highlights that blocking these immune checkpoints offer a promising therapeutic strategy for improving these patients prognosis.
• The role of immune cells in rare cancer Langerhans cell Histiocytosis.
As we approach the end of the financial year, you may be considering making a tax deductable donation to a worthwhile cause. The Institute is a regional organisation, making a world-class contribution to cancer research. We are grateful for the continued support of the community to ensure our future. We are a registered charity and all donations of $2 or more are tax deductible.
Once again, we thank you. It is only through your generous support that our work continues.